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报告题目:Synthetic Polypeptide Materials for Biomedical 


报  告 人:Prof. Timothy J. Deming
     Chair, Department of Bioengineering, UCLA




Timothy J. Deming
Chair, Department of Bioengineering, UCLA


8/1989 - 10/1993 University of California Berkeley, CA

Ph.D. in Chemistry, Advisor

Ph.D. thesis research with Dr. Bruce M. Novak

Research encompassing polymer synthesis using organometallic catalysis, elucidation of polymerization mechanisms, and physical properties of helical macromolecules.

9/1985 - 6/1989 University of California Irvine, CA

B.S. in Chemistry.

Undergraduate research with Dr. William J. Evans, 6/1987 - 6/1989.

Research activities involved exploration and expansion of the chemistry of cerium(IV) through synthesis of alkoxide and organometallic complexes.

Work Experience

7/06 – Present Chair, Bioengineering Department, UCLA

7/06 – 1/09 Chair, Biomedical Engineering, Interdepartmental Program, UCLA

7/04 – Present Professor, Bioengineering and Chemistry Departments, UCLA

7/03 - 6/04 Professor, Materials and Chemistry Departments, UCSB

7/99 - 6/03 Associate Professor, Materials and Chemistry Departments, UCSB

2/96 - 6/99 Assistant Professor. Materials and Chemistry Departments, UCSB

3/95 - 1/96 Assistant Professor, Materials Department, UCSB

11/93 - 3/95  Postdoctoral research associate with Professor David A. Tirrell

University of Massachusetts, Amherst, MA

Awards and Honors

IUPAC Macromolecular Division Young Scientist Award 2004

MRS Young Investigator Award 2003

Camille Dreyfus Teacher-Scholar 2000

3M Non-Tenured Faculty Award 1999

Beckman Young Investigator Award 1998-2000

Alfred P. Sloan Research Fellow 1998-2000

National Science Foundation CAREER Award 1997-2001

Office of Naval Research Young Investigator Award 1996-1999

University of California, Regents Junior Faculty Fellow 1996

ACS Unilever Award for Outstanding Graduate Research in Polymer Chemistry 1994

NIH National Research Service Award Postdoctoral Fellow 1993-1992

Selected Publications

1.     “Biocompatibility of Amphiphilic Diblock Copolypeptide Hydrogels in the Central Nervous System”. Yang, C.-Y.; Song, B.; Ao, Y.; Nowak, A. P.; Abelowitz, R. B.; Korsak, R. A.; Havton L. A.; Deming, T. J.; Sofroniew, M. V. Biomaterials, 2009, 30, 2881-2898.

2.     "Nanoscale Double Emulsions Stabilized by Single Component Block Copolypeptides" Hanson, J.A.; Chang, C.; Graves, S.; Li, Z.; Mason, T.G.; and Deming, T.J. Nature, 2008, 455, 85-88.

3.     "Synthetic Polypeptides for Biomedical Applications" Deming, T.J. Progress in Polymer Science, 2007, 32, 858-875.

4.     “Polyarginine Segments in Block Copolypeptides Drive Both Vesicular Assembly and Intracellular Delivery” Holowka, E. P.; Sun, V. Z.; Kamei, D. T.; Deming, T. J. Nature Materials, 2007, 6, 52–57.

5.     “Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization” Deming, T. J. Advances in Polymer Science, 2006, 202, 1-18.

6.     “Monoliths of Aligned Silica-Polypeptide Hexagonal Platelets” Bellomo, E. G.; Deming, T. J. J. Am. Chem. Soc. , 2006, 128, 2276-2279.

7.     “Charged Polypeptide Vesicles with Controllable Diameter” Holowka, E. P.; Pochan, D. J.; Deming, T. J. J. Am. Chem. Soc. , 2005, 127, 12423 - 12428.

8.     “Aqueous Cholesteric Liquid Crystals Using Uncharged Rod-Like Polypeptides” Bellomo, E. G.; Davidson, P.; Impéror-Clerc, M.; Deming, T. J. J. Am. Chem. Soc. 2004, 126, 9101-9105.

9.     “Rheology of Block Copolypeptide Solutions: Hydrogels with Tunable Properties”. Breedveld, V.; Nowak, A. P.; Sato, J.; Deming, T. J.; Pine, D. J. Macromolecules , 2004, 37, 3943-3953.

10.   “Stimuli Responsive Polypeptide Vesicles via Conformation Specific Assembly” Bellomo, E.; Wyrsta, M. D.; Pakstis, L.; Pochan, D. J.; Deming, T. J. Nature Materials, 2004, 3, 244-248.

11.   “Rapidly Recovering Hydrogel Scaffolds From Self-Assembling Diblock Copolypeptide Amphiphiles”. Nowak, A. P.; Breedveld, V.; Pakstis, L.; Ozbas, B.; Pine, D. J.; Pochan, D.; Deming, T. J. Nature , 2002, 417, 424-428.

12.   “A Parallel Synthetic Approach for the Analysis of Membrane Interactive Copolypeptides”. Wyrsta, M. D.; Cogen, A. L.; Deming, T. J. J. Am. Chem. Soc. , 2001, 123, 12919-12920.

13.   “Controlled Polymerization of b-Lactams Using Metal-Amido Complexes. Synthesis of Block Copoly(b-Peptides)”. Cheng, J.; Deming, T. J. J. Am. Chem. Soc., 2001, 123, 9457-9458.

14.   "Chain Initiation Efficiency in Cobalt- and Nickel-Mediated Polypeptide Synthesis". Deming, T. J. and Curtin, S. A. J. Am. Chem. Soc. , 2000, 122, 5710-5717.

15.   "Biomimetic Synthesis of Ordered Silica Structures Mediated by Block Copolypeptides". Cha, J. N.; Stucky, G. D.; Morse, D. E. and Deming, T. J. Nature , 2000, 403, 289-292.

16.   "Methylated Mono- and Diethyleneglycol Functionalized Polylysines: Nonionic, Helical, Water Soluble Polypeptides". Yu, M.; Nowak, A. P.; Pochan, D. P. and Deming, T. J. J. Am. Chem. Soc. , 1999, 121, 12210-12211.

17.   "Initiators for End-Group Functionalized Polypeptides via Tandem Addition Reactions". Curtin, S. A. and Deming, T. J. J. Am. Chem. Soc. , 1999, 121, 7427-7428.

18.   "Role of L-3,4-Dihydroxyphenylalanine in Mussel Adhesive Proteins". Yu, M.; Hwang, J.; Deming, T. J. J. Am. Chem. Soc. 1999, 121, 5825-5826.

19.    "Amino Acid Derived Nickelacycles: Intermediates in Nickel Mediated Polypeptide Synthesis". Deming, T. J. J. Am. Chem. Soc., 1998, 120, 4240-4241.

20.   "Facile Synthesis of Block Copolypeptides of Defined Architecture". Deming, T. J. Nature, 1997, 390, 386-389.

21.   "Transition Metal-Amine Initiators for Preparation of Well-Defined Poly(gamma-benzyl L-glutamate)". Deming, T. J. J. Am. Chem. Soc., 1997, 119, 2759-2760.




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