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报告题目:Foldamers: expanding the chemical space

报 告 人:Prof. Ivan HUC

European Institute of Chemistry and Biology



报告摘要:Our group has developed helical foldamers – oligomers that adopt stable helical folded conformations – derived from aromatic amino acids [1]. Some of these folded objects have shown unprecedented conformational stability [2], and constitute convenient building blocks to elaborate synthetic, very large (protein-sized) folded architectures (Figure 1) [3]. They possess a high propensity to assemble into double, triple and quadruple helices [4]. Cavities can be designed within such synthetic molecules that enable them to act as artificial receptors [5] including for chiral guests. Water soluble analogues of these foldamers show promise in nucleic acid recognition [6].

Figure 1. Crystal structure of a large foldamer comprised of two helices of opposite handedness at a 90° angle. The protein crystal structure on the right is shown as the same scale for size comparison.


S. Hecht, I. Huc (Eds), Foldamers: Structure, Properties, and Applications, 2007, Wyley-VCH, Weinheim, ISBN-13: 978-3-527-31563-5.

H. Jiang, J.-M. Léger, I. Huc, J. Am. Chem. Soc. 2003, 125, 3448; N. Delsuc, T. Kawanami, J. Lefeuvre, A. Shundo, H. Ihara, M. Takafuji, I. Huc ChemPhysChem 2008, 9, 1882.

C. Dolain, J.-M. Léger, N. Delsuc, H. Gornitzka, I. Huc Proc. Natl. Acad. Sci. (USA) 2005, 102, 16146; 5 N. Delsuc, J.-M. Léger, S. Massip, I. Huc Angew. Chem. Int. Ed. 2007, 46, 214; D. Sánchez-García, B. Kauffmann, T. Kawanami, H. Ihara, M. Takafuji, M.-H. Delville, I. Huc, J. Am. Chem. Soc. 2009, 131, 8642.

Q. Gan, C. Bao, B. Kauffmann, A. Grélard, J. Xiang, S. Liu, I. Huc, H. Jiang, Angew. Chem. Int. Ed. 2008, 47, 1715; D. Haldar, H. Jiang, J.-M. Léger, I. Huc, Angew. Chem. Int. Ed. 2006, 45, 5483; Y. Ferrand, A. Kendhale, J. Garric, B. Kauffmann, I. Huc, Angew. Chem. Int. Ed. 2010, 49, 1718.

Bao, B. Kauffmann, Q. Gan, K. Srinivas, H. Jiang; I. Huc Angew. Chem. Int. Ed. 2008, 47, 4153; Y. Ferrand, A. M. Kendhale, B. Kauffmann, A. Grélard, C. Marie, V. Blot, M. Pipelier, D. Dubreuil, I. Huc, J. Am. Chem. Soc. 2010, 132, 7858.

P. S. Shirude, E. R. Gillies, S. Ladame, F. Godde, K. Shin-ya, I. Huc, S. Balasubramanian, J. Am. Chem. Soc. 2007, 129, 11890.

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